Public Guest Talk: Prof. Dr. Daniel Huster – Institute of Medical Physics and Biophysics, University of Leipzig
The RTG welcomes Daniel Huster as a guest speaker on Tuesday, 10th December 2019.
Titel: “Small Molecules Modulate the Properties of Cholesterol-Containing Membranes”
Cholesterol has been known to play a decisive role in biological membranes. In the talk, I shall be discussing specific molecular properties of cholesterol with regard to its specific function in the maintenance of the membrane’s barrier function. Especially, the length of cholesterol’s side chain will be addressed [1]. I will continue presenting data on the specific interaction of cholesterol with lipids in mixed membranes [2] and raft mixtures [3,4]. Next, I will be presenting unpublished data on the modulation of the lateral organization of raft mixtures by small neurotransmitters. Finally, an example of the modulation of the structural dynamics of a membrane protein by membrane cholesterol will be given. In our group, we use solid-state NMR techniques to study membranes of mixed complexity on a molecular level.
[1] H. A. Scheidt, T. Meyer, J. Nikolaus, D. J. Baek, I. Haralampiev, L. Thomas, R. Bittman, P. Müller, A. Herrmann, D. Huster. Cholesterol’s aliphatic side chain structure modulates membrane properties. Angew. Chemie Int. Ed. 52 (2013) 12848-12851.
[2] D. Huster, K. Arnold, K. Gawrisch. Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid membranes. Biochemistry 37 (1998) 17299-17308.
[3] A. Bunge, P. Müller, M. Stöckl, A. Herrmann, D. Huster. Characterization of the ternary mixture of sphingomyelin, POPC, and cholesterol. Support for an inhomogeneous lipid distribution at high temperature. Biophys. J., 94 (2008) 2680-2690.
[4] O. Engberg, H. A. Scheidt, J. P. Slotte, D. Huster. Membrane localization and lipid interactions of common lipid-conjugated fluorescence probes. Langmuir 35 (2019) 11902-11911.
Official announcement: RTG1962_Huster
Research profile of Prof. Dr. Daniel Huster, University of Leipzig [link]
Venue: Department Biology, Building B1, Floor 00, Seminar Room Cell Biology (00.581), Staudtstraße 5, 91058 Erlangen.
Time: 5.00 p.m. (s.t.) –> Drinks will be served, starting at 4.30 p.m.