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Public Guest talk: Dr. Elisabeth Fischer-Friedrich, TU Dresden

The RTG welcomes Dr. Elisabeth Fischer-Friedrich as a Guest speaker on Tuesday, 7th of November 2017.

Titel: “Rheology of the active cortex in mitosis“

The cell cortex is a key structure for the regulation of cell shape and tissue organization. To reach a better understanding of the mechanics and dynamics of the cortex, we studied HeLa cells in mitosis as a simple model system. In our assay, cells are dynamically compressed between two parallel plates. Our measurements indicate that  the cortical layer is the dominant mechanical element in mitosis as opposed to the cytoplasmic interior.
To characterize the time-dependent rheological response, we extracted a complex elastic modulus which characterizes the resistance of the cortex against area dilation.  In this way, we arrived at a rheological characterization of the cortical actomyosin network  in the linear regime.
Furthermore, we investigated the influence of actin cross-linkers and the impact of active prestress on rheological behavior.  Notably, we find that cell mechanics in mitosis is captured by a simple rheological model characterized by a slowest relaxation time scale of 10 seconds which marks the onset of fluidity in the system.

Official announcement: RTG1962_Fischer-Friedrich

Research profil of Dr. Elisabeth Fischer-Friedrich: Biotechnology Center of TU Dresden [link]

Venue: Department Biology, Building B1, Floor 00, Seminar Room Cell Biology (00.581), Staudtstraße 5, 91058 Erlangen.

Time: 5.00 p.m. (s.t.) –> Drinks will be served, starting at 4.30 p.m.