Public Guest talk: Dr. Dirk Mielenz, FAU Erlangen-Nürnberg
The RTG welcomes Dirk Mielenz as a Guest speaker on Tuesday, 9th of January 2018.
Titel: “The role of Swiprosin-1/EFhd2 in drug addiction and neurodegenereration“
Swiprosin-1/EFhd2 (EFhd2) is a 30 kDa, Ca2+ binding and actin bundling protein that we originally identified in “lipid rafts” as B cell receptor signaling molecule. Work by us and others has shown that EFhd2 controls actin dynamics and kinesin mediated transport along microtubules, thereby, influencing lamellipodia formation and cell migration in several cell types. EFhd2 is expressed strongly in many regions in the brain and associates with a mutated form of the microtubule binding protein tau, which causes frontotemporal dementia and parkinsonism. Our recent work has shown that EFhd2 controls abundance of tau and hippocampal neurogenesis as well as cortex volume, likely via regulating the Pax6/Eomes axis. We also found that EFhd2 is a resilience factor against alcohol abuse in mice, with SNPs of EFhd2 associated with anxiety behavior and binge drinking in humans. In summary, EFhd2 regulates important and conserved signaling events in the immune and nervous system, possibly by mediating membrane-nucleus communication via the cytoskeleton.
Official announcement: RTG1962_Dirk Mielenz
Research profil of Dr. Dirk Mielenz: Research Group Leader at FAU Erlangen-Nürnberg [link]
Venue: Department Biology, Building B1, Floor 00, Seminar Room Cell Biology (00.581), Staudtstraße 5, 91058 Erlangen.
Time: 5.00 p.m. (s.t.) –> Drinks will be served, starting at 4.30 p.m.